Herders of Indian and European Cattle Share Their Predominant Allele for Lactase Persistence
نویسندگان
چکیده
منابع مشابه
The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China.
The frequency of lactase persistence varies widely in human populations. Study showed that the T allele of a C/T transition 13910bp upstream from exon 1 of lactase gene (LCT) was completely associated with lactase persistence in a Finnish population. To evaluate if the frequency of -13910T allele was in concordance with the lactase persistence in northern Chinese populations, in this study, we ...
متن کاملEvolution of Lactase Persistence
Though humans are known to lose lactase ability post-weaning, some people maintain lactase production into adulthood, a condition known as lactase persistence. Global distribution patterns of lactase persistency are inconsistent; the condition is much more prevalent in some populations than others. Using results across independent studies, the existence of such a phenomenon can be attributed to...
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Ruminant milk and dairy products are important food resources in many European, African, and Middle Eastern societies. These regions are also associated with derived genetic variants for lactase persistence. In mammals, lactase, the enzyme that hydrolyzes the milk sugar lactose, is normally down-regulated after weaning, but at least five human populations around the world have independently evo...
متن کاملMolecular Genetics of Lactase Persistence
This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. In addition, some unpublished data are presented Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene. Identification of a variant associated with adult-type hypolactasia. Transcriptional regul...
متن کاملGenetics of lactase persistence and lactose intolerance.
The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase. In other healthy humans, lactase activity persists at a high level throughout adult life, enabling them to digest lact...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2011
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msr190